Michael S replied: "Naltrexone is a MU antagonist meaning that it will go onto the MU receptors (the main receptors that heroin and all opioids hit and activate) so if someone was on naltrexone and had enough of it taking a dose of heroin depending on the amont of heroin they wouldn't get as many effects.
Now heroin and other opioids do hit other opioid receptors such as kappa and delta (i think thats what its called) these effects aren't as well known but they are thought to not be positive. the high/pain relief is thought to be primarily from the MU receptors. Since naltrexone blocks primarily the mu receptors those other receptors would be hit and some effects would be seen.
Alcoholics are sometimes given naltrexone for no other reason then it helps calm them down and has been shown to help prevent relapses. There really is no pharmacological reason to give naltrexone to alcoholics. If you took naltrexone while drinking it would NOT alter the effects of alcohol.
Naltrexone is a competitive inhibitor for the MU receptors so it still is possible to OD while on naltrexone. Number 1 naltrexone won't last forever in the body it will be gone after i'd say 8 hours. Number 2 naltrexone althought it can bind to the MU receptor it acts competitively which means if morphine or heroin were at much higher concentraions it could displace the naltrexone and give the MU effects. By the way the ODing part is also from the MU effects. So yes you can die from heroin even if on naltrexone.
Of course all the other complications from heroin high risk for infection due to the IV use, heart infections, and addiction still exist. You'd have to be pretty stupid to use that stuff anyway but people do everyday."
Chelsea replied: "Yes, many have been taking it for years, especially with MS. LDN stimulates endorphins and met-enkephalin (opioid growth factor) which serve to re balance the immune system so it behaves correctly, and thus stops attacking the host. The beta endorphins and met-enkephalin also stimulate the proliferation of repair cells in the body. They also act to counteract the effects of oxidative stress which has been linked with the degenerative progressive stage of MS, and may well prove to be a primary process in MS. Essentially, the combination of a correctly functioning immune system and the proliferation of repair cells, like the oligodendrocytes that make myelin for the nerves, and the antioxidant effects work to overcome and even reverse the effects of MS . Permanent damage however will have to wait for stem cell therapy, but this explains some of the miraculous improvements that have been recorded with LDN.
As we all know, autoimmune diseases are a result of an under-active immune system by showing low beta-endorphin levels. Endorphins are what regulate the immune system. When you raise the endorphin level, disease progression starts to slow and can come to a complete halt in many. LDN raises endorphin levels."
Naltrexone v.s Heroin??? I heard that if you are taking Naltrexone and try a Heroin there will be no efects, or maybe u will feel sick?Which one is true?Is there anyway you can feel high from Heroin while using Naltrexone?How can u get an overdose from Heroin while using Naltrexone ?What about Naltrexone v.s Alcohol?
Thanx
Phoenix replied: "Do not use narcotic drugs or alcohol while taking naltrexone oral. Never try to overcome the effects of the medication by taking large doses of narcotic drugs or alcohol. Doing so could result in dangerous effects, including coma and death. Ask your doctor before using any prescription or over-the-counter medicine to treat a cold, cough, diarrhea, or pain while taking naltrexone oral. These medicines may contain narcotics or alcohol. Naltrexone oral can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Carry an ID card or wear a medical alert bracelet stating that you are using naltrexone, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are using this medication"
ash v replied: "Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. The blockade of opioid receptors is the basis behind its action in the management of opioid dependence—it reversibly blocks or attenuates the effects of opioids. Naltrexone is sometimes used for rapid detoxification regimens for opioid dependence. The main use of naltrexone is for the treatment of alcohol dependence. It essentially counters the effect of opioids and alcohol."
naltrexone and perocet? hi, im in no way an opiate addict, but i recently took a percocet last night. i am using naltrexone for alcohol problems. i heard that your not supposed to combine the two in case of a withdrawel or something ? ?but im not an opiate addict, so i was wondering is it ok to take the first dose of naltrexone tonight if i took a percocet last night? i could swear i read somewhere your supposed to wait a few days or something..
Blondie replied: "you need to call a pharmacy instead of asking on here."
any experiences with naltrexone? did it work for you? how long where you on it? did your body and mind get used to it?
Avery Jane replied: "It's black-boxed for liver enzyme elevation. The IM drug can cause nasty injection-site reactions. Get your blood drawn when they tell you to."

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